Human Serum Thyroglobulin and Thyroid Nodules
نویسندگان
چکیده
منابع مشابه
Serum thyroglobulin and thyroid cancer.
Thyroglobulin is a large glycosylated protein (MW 660000 daltons) which is synthesised and secreted by the thyroid cell into the follicular lumen. In the thyroglobulin molecule the iodotyrosines undergo oxidative coupling to form the iodothyronines thyroxine (T4) and triiodothyronine (T3). Production of thyroid hormones results from micropinocytosis of iodinated thyroglobulin from the colloid i...
متن کاملPreoperative measurement of serum thyroglobulin to predict malignancy in thyroid nodules: a systematic review.
Several articles have assessed the role of preoperative serum thyroglobulin (Tg) as predictor of malignancy of thyroid nodules, with particular focus on nodules with indeterminate cytology. However, the role of serum Tg as diagnostic marker remains unclear. The aim of the study was to perform a systematic review to add more evidence-based data on this topic. A comprehensive literature search wa...
متن کاملPreoperative Serum Thyroglobulin as a Useful Predictive Marker to Differentiate Follicular Thyroid Cancer from Benign Nodules in Indeterminate Nodules
Indeterminate cytology results increase the number of repetitive procedure and unnecessary surgery. This study was designed to find useful and simple predictive tools to differentiate malignant thyroid nodules from indeterminate nodules. We retrospectively enrolled 164 patients who had undergone thyroid surgery as a result of indeterminate cytology in the National Cancer Center. We reviewed pat...
متن کاملProduction of anti-human thyroglobulin and anti-thyroid hormone antibodies in rabbits immunized with human thyroglobulin.
Two rabbits (TG-1, TG-2) were immunized with human thyroglobulin (HTg) and bled serially. Antisera were obtained at different times after the first immunization and kept separately and studied. In both rabbits production of anti-HTg, and anti-thyroid hormone antibodies such as anti-thyroxine (T4) and anti-triiodothyronine (T3) antibodies was observed. Binding parameters of anti-HTg antibodies w...
متن کامل[Serum thyroglobulin levels in patients with thyroid tumor].
Serum thyroglobulin (Tg) levels were measured in 15 normal volunteers, 69 patients with differentiated thyroid carcinoma, 22 with adenoma, 45 with adenomatous goiter, 5 with functioning adenoma and 24 with Graves' disease, utilizing a double antibody radioimmunoassay technique. Serum Tg levels in the normal volunteers were found to be less than 30 ng/ml as determined from their mean value, i.e....
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1981
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.57.6_930